Publications
See also:
MSc. Thesis/Project
- Title: Joint modeling of functional ability measures and competing risk for stroke patients. Journal: Bahir Dar University
Abstract
Background: In many clinical trials, patients who are followed up over time may typically experience multiple events. Ignoring such competing risk events in time-to-event analyses can lead to biased risk estimates. In this context, we presented joint modeling of functional ability measures and the competing risk among stroke patients at FHCSH Bahir Dar, Ethiopia.
Methods: We considered 400 stroke patients under the medical ward outpatient stroke at FHCSH who started treatment from September 2018 to August 2021 by a retrospective cohort study design,patients with CT scan or MRI confirmation, patients with age greater than or equal to 18 years,and patients with at least three visits were included in this study. For this purpose, we employed a joint model of longitudinal ordinal with competing risk.
Result: Among different candidates of demographic and clinical variables, age, diabetes, blood urea nitrogen, Glasgow coma scale, white blood cell count, and stroke complication were statistically significant predictors in the longitudinal sub-model for functional ability. Likewise,age, diabetes, cholesterol level, white blood cell count, atrial fibrillation, types of strokes, and stroke complications were statistically significant predictors in the cause-specific hazard submodel for time to death and dropouts. Finally, age,diabetes,white blood cell count,and stroke complication were statistically significant predictors that jointly affected the two sub-model. Additionally, associations between both joint model and competing risk were statistically significant.
Conclusion: The joint competing risk modeling approach, provides wide-ranging information about the transition pattern of the disease, with associated improved knowledge of disease etiology.
Recommendation: The results of the study can be used as a motivation for future scholars. since stroke is one of the most frequent diseases in Ethiopia as well as in the world, it needs more attention and study in a wider study area.
Keywords:- modified Rankin Scale, Proportional Hazard, Cause-Specific, Cumulative Incidence Function, Partial-Proportional Odds
Supervisors:
Name: Dr Zelalem G, Dessie
Email: zelalem_getahune@yahoo.com
Address: University of KwaZulu Natal, South Africa
Name: Dr Lijalem Melie Tesfaw
Email: lijalemmelie@gmail.com
Address: university of Queensland, Australia
Publications
Title: Exploring functional abilities and competing risks among stroke patients: a longitudinal and survival analysis study at Felege Hiwot Referral Hospital, Ethiopia. 2024. 14(5): p. e073384.
Journal: BMJ Open. doi
Title: Spatial variation of short birth intervals and their determinant factors among reproductive women in Ethiopia using a geographically weighted regression model. 2024. 11: p. 1363844.
Journal: Frontier in Medicine doi
Under Review
Title: Competing Risks analysis in a case of stroke patients at felege hiwot referral hospital, Bahir Dar Ethiopia. Frontier in stroke. 2024. 10:1442989
Journal: Frontier in Stroke link
Title. Modelling spatial distribution and determinants of home delivery in Ethiopia: geographically weighted regression.
Journal: Scientific report
Title. Identifying factors that determine functional status of stroke patients using partial proportional odds model at Felege Hiwot referral hospital Ethiopia. 2024.
Journal: Scientific report
Title. Maru Z, Haymanot B, Awoke S,.2023. Determinants of blood sugar level and time to first remission for type 1 diabetic patients under treatment; Comparison of separate and joint models.
Journal: Hematology and Oncology
Title. Trend and Forecast of Measles Disease, In East Gojjam Zone, Amhara Region, Northwest Ethiopia
Journal: Health, Population and Nutrition
Under preparations
Title: Understanding Trends and Determinants of Healthcare Utilization for Common Childhood Illnesses in Ethiopia
Title: Exploring frailty and factor identification in women who had breast cancer at Felege Hiwot referral hospital, Ethiopia
Title: Joint modelling of CD4 cell count change and adherence to HAART at Injibara general hospital, Ethiopia
Title: Determinant factor of longitudinal pulse pressure among hypertensive patients treated Assosa general hospital, Ethiopia
Title: Major risk factors on time to recovery and competing lost follow up among diabetic patients at Felege Hiwot referral hospital, Ethiopia